Site icon Vivid Bling

Bidirectional relations between the maternal and infant gut microbiome and behavior

Bidirectional relations between the maternal and infant gut microbiome and behavior
  • Cowan, C. S., Dinan, T. G. & Cryan, J. F. Annual Research Review: Critical Windows–the Microbiota–Gut–Brain Axis in Neurocognitive Development. J. Child Psychol. Psychiatry 61, 353–371 (2019).

  • Cryan, J. F. & Dinan, T. G. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat. Rev. Neurosci. 13, 701 (2012).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Vatanen, T. et al. Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism. Cell 185, 4921–4936.e4915 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wang, M., Monaco, M. H. & Donovan, S. M. Impact of early gut microbiota on immune and metabolic development and function. Semin. Fetal Neonatal Med. 21, 380–387 (2016).

    Article 
    PubMed 

    Google Scholar 

  • Dominguez-Bello, M. G. et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc. Natl. Acad. Sci. USA 107, 11971–11975 (2010).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Moore, R. E. & Townsend, S. D. Temporal development of the infant gut microbiome. Open Biol. 9, 190128 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Pannaraj, P. S. et al. Association between breast milk bacterial communities and establishment and development of the infant gut microbiome. JAMA Pediatr. 171, 647–654 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Turnbaugh, P. J. et al. The Human Microbiome Project. Nature 449, 804–810 (2007).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Grech, A. et al. Maternal exposures and the infant gut microbiome: a systematic review with meta-analysis. Gut Microbes 13, 1897210 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ferretti, P. et al. Mother-to-infant microbial transmission from different body sites shapes the developing infant gut microbiome. Cell Host Microbe 24, 133–145.e135 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Aizawa, E. et al. Possible association of bifidobacterium and lactobacillus in the gut microbiota of patients with major depressive disorder. J. Affect. Disord. 202, 254–257 (2016).

    Article 
    PubMed 

    Google Scholar 

  • Jiang, N. M. et al. Early life inflammation and neurodevelopmental outcome in bangladeshi infants growing up in adversity. Am. J. Trop. Med. Hyg. 97, 974–979 (2017).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Bastiaanssen, T. F. et al. Gutted! Unraveling the Role of the Microbiome in Major Depressive Disorder. Harv. Rev. Psychiatry 28, 26–39 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Xie, Z. et al. Integrated multi-omics analysis reveals gut microbiota dysbiosis and systemic disturbance in major depressive disorder. Psychiatry Res. 334, 115804 (2024).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Ertel, K. A., Rich-Edwards, J. W. & Koenen, K. C. Maternal depression in the united states: nationally representative rates and risks. J. Women’s. Health 20, 1609–1617 (2011).

    Article 

    Google Scholar 

  • Field, T. Postpartum depression effects on early interactions, parenting, and safety practices: a review. Infant Behav. Dev. 33, 1–6 (2010).

    Article 
    PubMed 

    Google Scholar 

  • Shapiro, A. F., Jolley, S. N., Hildebrandt, U. & Spieker, S. J. The effects of early postpartum depression on infant temperament. Early Child Dev. Care 190, 1918–1930 (2020).

    Article 
    PubMed 

    Google Scholar 

  • Aatsinki, A.-K. et al. Gut microbiota composition is associated with temperament traits in infants. Brain, Behav., Immun. 80, 849–858 (2019).

    Article 
    PubMed 

    Google Scholar 

  • Carlson, A. L. et al. Infant gut microbiome composition is associated with non-social fear behavior in a pilot study. Nat. Commun. 12, 3294 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Fox, M. et al. Development of the infant gut microbiome predicts temperament across the first year of life. Development and Psychopathology, 1–12 (2021).

  • Kelsey, C. M. et al. Gut microbiota composition is associated with newborn functional brain connectivity and behavioral temperament. Brain Behav. Immun. 91, 472–486 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Kelsey, C. M. & Grossmann, T. A call for mapping the development of the microbiota-gut-brain axis during human infancy. Behav. Brain Sci. 42, e74 (2019).

    Article 

    Google Scholar 

  • Kelsey, C. M., Dreisbach, C., Alhusen, J. & Grossmann, T. A primer on investigating the role of the microbiome in brain and cognitive development. Dev. Psychobiol. 0, 1–9 (2018).

    Google Scholar 

  • Alving-Jessep, E., Botchway, E., Wood, A. G., Hilton, A. C. & Blissett, J. M. The development of the gut microbiome and temperament during infancy and early childhood: a systematic review. Dev. Psychobiol. 64, e22306 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Portlock, T. et al. Interconnected pathways link faecal microbiota plasma lipids and brain activity to childhood malnutrition related cognition. Nat. Commun. 16, 473 (2025).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Turroni, F. et al. The infant gut microbiome as a microbial organ influencing host well-being. Ital. J. Pediatr. 46, 16 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ueda, E. et al. Temperament in early childhood is associated with gut microbiota composition and diversity. Dev. Psychobiol. 66, e22542 (2024).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Koenig, J. E. et al. Succession of Microbial Consortia in the developing infant gut microbiome. Proc. Natl. Acad. Sci. USA 108, 4578–4585 (2011).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Enav, H., Bäckhed, F. & Ley, R. E. The developing infant gut microbiome: a strain-level view. Cell Host Microbe 30, 627–638 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Tanaka, M. & Nakayama, J. Development of the gut microbiota in infancy and its impact on health in later life. Allergol. Int. 66, 515–522 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Kochanska, G., Coy, K. C. & Murray, K. T. The development of self-regulation in the first four years of life. Child Dev. 72, 1091–1111 (2001).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Grossmann, T. & Jessen, S. When in infancy does the “Fear Bias” Develop?. J. Exp. Child Psychol. 153, 149–154 (2017).

    Article 
    PubMed 

    Google Scholar 

  • Opie, R. S., Uldrich, A. C. & Ball, K. Maternal Postpartum diet and postpartum depression: a systematic review. Matern. Child Health J. 24, 966–978 (2020).

    Article 
    PubMed 

    Google Scholar 

  • Xia, M., Luo, J., Wang, J. & Liang, Y. Association between breastfeeding and postpartum depression: a meta-analysis. J. Affect. Disord. 308, 512–519 (2022).

    Article 
    PubMed 

    Google Scholar 

  • Krol, K. M. & Grossmann, T. Psychological effects of breastfeeding on children and mothers. Bundesgesundheitsblatt – Gesundheitsforschung – Gesundheitsschutz 61, 977–985 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Murphy, J. R., Paul, S., Dunlop, A. L. & Corwin, E. J. Maternal peripartum antibiotic exposure and the risk of postpartum depression. Res. Nurs. Health 41, 369–377 (2018).

    Article 

    Google Scholar 

  • Slykerman, R. F., Neumann, D., Underwood, L., Hobbs, M. & Waldie, K. E. Age at first exposure to antibiotics and neurodevelopmental outcomes in childhood. Psychopharmacology 240, 1143–1150 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Dagher, R. K., Bruckheim, H. E., Colpe, L. J., Edwards, E. & White, D. B. Perinatal depression: challenges and opportunities. J. Women’s. Health 30, 154–159 (2021).

    Article 

    Google Scholar 

  • Sharp, J. R. et al. Temperament is associated with outdoor free play in young children: a target kids! Study. Acad. Pediatr. 18, 445–451 (2018).

    Article 
    PubMed 

    Google Scholar 

  • Davidov, M., Knafo-Noam, A., Serbin, L. A. & Moss, E. The influential child: how children affect their environment and influence their own risk and resilience. Dev. Psychopathol. 27, 947–951 (2015).

    Article 
    PubMed 

    Google Scholar 

  • Esposito, G., Hiroi, N. & Scattoni, M. L. Cry, baby, cry: expression of distress as a biomarker and modulator in autism spectrum disorder. Int. J. Neuropsychopharmacol. 20, 498–503 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Eisenberg, N., Taylor, Z. E., Widaman, K. F. & Spinrad, T. L. Externalizing symptoms, effortful control, and intrusive parenting: a test of bidirectional longitudinal relations during early childhood. Dev. Psychopathol. 27, 953–968 (2015).

    Article 
    PubMed 

    Google Scholar 

  • Wiley, K. S. et al. Contact with caregivers is associated with composition of the infant gastrointestinal microbiome in the first 6 months of life. Am. J. Biol. Anthropol. 183, e24858 (2024).

    Article 
    PubMed 

    Google Scholar 

  • Stern, J. A., Beijers, R., Ehrlich, K. B., Cassidy, J. & de Weerth, C. Beyond early adversity: the role of parenting in infant physical health. J. Dev. Behav. Pediatr. 41, 452–460 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Dinan, K. & Dinan, T. Antibiotics and mental health: the good, the bad and the ugly. J. Intern. Med. 292, 858–869 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Mcculloch, J. Just a Microbiology System (JAMS), (2023).

  • Davar, D. et al. Fecal microbiota transplant overcomes resistance to Anti–Pd-1 therapy in melanoma patients. Science 371, 595–602 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Dreisbach, C. et al. Composition of the maternal gastrointestinal microbiome as a predictor of neonatal birth weight. Pediatr. Res. (2023).

  • Rosshart, S. P. et al. Laboratory mice born to wild mice have natural microbiota and model human immune responses. Science 365, eaaw4361 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Gartstein, M. A. & Rothbart, M. K. Studying infant temperament via the revised infant behavior questionnaire. Infant Behav. Dev. 26, 64–86 (2003).

    Article 

    Google Scholar 

  • Putnam, S. P., Helbig, A. L., Gartstein, M. A., Rothbart, M. K. & Leerkes, E. Development and assessment of short and very short forms of the infant behavior questionnaire-revised. J. Pers. Assess. 96, 445–458 (2014).

    Article 
    PubMed 

    Google Scholar 

  • Putnam, S. P., Gartstein, M. A. & Rothbart, M. K. Measurement of fine-grained aspects of toddler temperament: the early childhood behavior questionnaire. Infant Behav. Dev. 29, 386–401 (2006).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Cox, J. L., Holden, J. M. & Sagovsky, R. Detection of postnatal depression. development of the 10-item edinburgh postnatal depression scale. Br. J. Psychiatry 150, 782–786 (1987).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Brouwers, E. P., van Baar, A. L. & Pop, V. J. Does the Edinburgh postnatal depression scale measure anxiety?. J. Psychosom. Res 51, 659–663 (2001).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • R Core Team. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing. Retrieved from (2022).

  • Bates, D., Mächler, M., Bolker, B. & Walker, S. Fitting linear mixed-effects models using Lme4. J. Stat. Softw. 67, 1–48 (2015).

    Article 

    Google Scholar 

  • Plummer, M., Stukalov, A. & Denwood, M. Rjags: Bayesian Graphical Models Using MCMC. R Package Version 4 (2016).

  • Yassour, M. et al. Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability. Sci. Transl. Med. 8, 343ra381 (2016).

    Article 

    Google Scholar 

  • Vatanen, T. et al. Variation in microbiome lps immunogenicity contributes to autoimmunity in humans. Cell 165, 842–853 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Roswall, J. et al. Developmental trajectory of the healthy human gut microbiota during the first 5 years of life. Cell Host Microbe 29, 765–776.e763 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Bäckhed, F. et al. Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe 17, 690–703 (2015).

    Article 
    PubMed 

    Google Scholar 

  • Stewart, C. J. et al. Temporal development of the gut microbiome in early childhood from the Teddy Study. Nature 562, 583–588 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Jost, T., Lacroix, C., Braegger, C. & Chassard, C. Stability of the maternal gut microbiota during late pregnancy and early lactation. Curr. Microbiol. 68, 419–427 (2014).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Samarra, A. et al. Maternal-infant antibiotic resistance genes transference: what do we know?. Gut Microbes 15, 2194797 (2023).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Machlitt-Northen, S. et al. Polygenic scores for schizophrenia and major depression are associated with psychosocial risk factors in children: evidence of gene–environment correlation. J. Child Psychol. Psychiatry 63, 1140–1152 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Quist, M. et al. Interactive effects of infant gestational age and infant fussiness on the risk of maternal depressive symptoms in a nationally representative sample. Acad. Pediatr. 19, 917–924 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Radjabzadeh, D. et al. Gut microbiome-wide association study of depressive symptoms. Nat. Commun. 13, 7128 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Zhang, J. & Pang, W. Gut microbiota and postpartum depression: a Mendelian randomization study. Front. Psychiatry 15, 1282742 (2024).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Parker, D. & Prince, A. Immunopathogenesis of Staphylococcus Aureus Pulmonary Infection. Semin. Immunopathol. 34, 281–297 (2012).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Mirsepasi-Lauridsen, H. C., Vallance, B. A., Krogfelt, K. A. & Petersen, A. M. Escherichia Coli Pathobionts associated with inflammatory bowel disease. Clin. Microbiol. Rev. 32, 1–16 (2019).

  • Lou, M. et al. Deviated and early unsustainable stunted development of gut microbiota in children with autism spectrum disorder. Gut 71, 1588–1599 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Alcock, B. P. et al. Card 2023: expanded curation, support for machine learning, and resistome prediction at the comprehensive antibiotic resistance database. Nucleic Acids Res. 51, D690–d699 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Fan, S. et al. Ceftriaxone regulates glutamate production and vesicular assembly in presynaptic terminals through Glt-1 in App/Ps1 Mice. Neurobiol. Learn. Mem. 183, 107480 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Zhao, Z. et al. Long-term exposure to Ceftriaxone sodium induces alteration of gut microbiota accompanied by abnormal behaviors in mice. Front Cell Infect. Microbiol. 10, 258 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ding, P., Lu, J., Wang, Y., Schembri, M. A. & Guo, J. Antidepressants promote the spread of antibiotic resistance via horizontally conjugative gene transfer. Environ. Microbiol. 24, 5261–5276 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kapourchali, F. R. & Cresci, G. A. M. Early-life gut microbiome—the importance of maternal and infant factors in its establishment. Nutr. Clin. Pract. 35, 386–405 (2020).

    Article 
    PubMed 

    Google Scholar 

  • Sharon, G. et al. Specialized metabolites from the microbiome in health and disease. Cell Metab. 20, 719–730 (2014).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Davies, S. M., Silverio, S. A., Christiansen, P. & Fallon, V. Maternal-infant bonding and perceptions of infant temperament: the mediating role of maternal mental health. J. Affect. Disord. 282, 1323–1329 (2021).

    Article 
    PubMed 

    Google Scholar 

  • Wang, Y. et al. Association between gut microbiota and infant’s temperament in the first year of life in a Chinese birth cohort. Microorganisms 8, 753 (2020).

  • Cardona, S. et al. Storage conditions of intestinal microbiota matter in metagenomic analysis. BMC Microbiol. 12, 158 (2012).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Guo, Y. et al. Effect of short-term room temperature storage on the microbial community in infant fecal samples. Sci. Rep. 6, 26648 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Liang, Y. et al. Systematic analysis of impact of sampling regions and storage methods on fecal gut microbiome and metabolome profiles. mSphere 5, e00763–00719 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Shaw, A. G. et al. Latitude in sample handling and storage for infant faecal microbiota studies: the elephant in the room?. Microbiome 4, 40 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Donaldson, G. P., Lee, S. M. & Mazmanian, S. K. Gut biogeography of the bacterial microbiota. Nat. Rev. Microbiol. 14, 20 (2016).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Shalon, D. et al. Profiling the human intestinal environment under physiological conditions. Nature 617, 581–591 (2023).

  • link

    Exit mobile version